|
Main
characteristics of CRABYON
|
Safety
data of CRABYON
Acute Toxicity
Test (Chitin)
LD 50(lethal dose 50): Over 3,000mg/Kg
The term lethal dose 50 is defined as the
dose of a substance which is fatal to 50%
of the test animals. More specifically. Lethal
dose 50 means that if chitin is orally administred
to mice on the basis of 3,000mg/Kg (mouse
weight), 50% of them die.
Mutagenicity
Test (Chitin)
Mutagenicity Test: Negative
This
test is conducted to determine whether or
not the test animals undergo an abrupt change
in the genotype of organ.
Positive: Mutagenic
Negative: not Mutagenic
Skin irritation Patch Test *
Patch Test: 1B (almost negative)
To be in compliance with JAFET (Japanese Association
for the Functional Evaluation of Textile),
the fabric in question has to be at least
almost negative.
* A test in which material is applied and
left in contact with skin surfaces for 48
hours to check tissue sensivity.
Clinical tests of
whether "CRABYON underwear" will
improve patients of atopic dernatitis.
Purpose
The objective is to determine whether CRABYON,
with many characteristics can alleviate
the symptom of atopic dermatitis.
Tester of CRABYON underwear
A doctor of medicine who runs a pediatrics
in Osaka, Japan.
Test Specimen
Half-sleeved underwear of blended fabric
(30% Crabyon / 70% cotton).
Testees (patients)
The doctor selected 11 patients from among
his outpatients, whose symptoms are relatively
stable and whom he can be reach easily for
consultation.
a. Test period: January to March, 1996
b. The number of testees: 11 patients
c. Age: Children of 2 year 3 month to 11
years 3 month old.
Test Method
All 11 testees wore CRABYON underwear after
obtaining their parents consent. Three pieces
of underwear were goven to each testees
who wore them one after another and were
washed after each use. The doctor and parents
saw each testee every two weeks. After eight
weeks, he evaluated whether or not the CRABYON
underwear improved patients of atopic dermatitis.
Efficacy Evaluation
|
|
Category |
|
|
5
|
Improved
considerably |
|
4
|
Improved |
|
3
|
Improved
a little |
|
2
|
Remain
unchanged |
|
1
|
Aggravated |
|
a. Doctor'sComments
He recorded the skin conditions such as itch,
dryness and scratches every two weeks and
classified them into five categories: |
|
Category |
|
|
5
|
Very
effective |
|
4
|
Effective |
|
3
|
Somewhat
effective |
|
2
|
Not effective |
|
1
|
Unknown |
|
b. Overall Evaluation
Considering the skin conditions, use of medicine
and food, he classified the underwear's effectiveness
into five categories: |
| Test Results
|
|
2-3 years old
|
3 persons |
|
3-4
|
2 |
|
4-5
|
1 |
|
5-6
|
1 |
|
6-7
|
2 |
|
7-8
|
- |
|
8-9
|
1 |
|
9-10
|
- |
|
10-
|
1 |
|
|
11
persons |
|
a. Testees Age Group |
|
Category |
|
|
5 (improved considerably)
|
"0"
persons |
|
4 (improved)
|
2 |
|
3 (somewhat improved)
|
5 |
|
2 (remain unchanged)
|
4 |
|
1 (aggravated)
|
0 |
|
b. Test results
He classified the testees skin conditions
as follows: |
He classified the effectiveness of CRABYON
underwear as follows: |
|
Category |
|
|
5 (very effective)
|
1
person(s) |
|
4 (effective)
|
1 |
|
3 (somewhat effective)
|
4 |
|
2 (not effective)
|
3 |
|
1 (unknown)
|
2 |
|
c. Side effects
All 11 testees experienced no side effects
of CRABYON at the end of two month-long wear
test. At the end of the test, it is considered
that the CRABYON underwear is safe. |
|
d. Time dependent change of skin conditions
Table 1 and Fig. 9 show how skin conditions
changed over time. (Weighted average of
five categories)
|
Table1 - Time dependent
change of skin conditions
|
|
|
Itch
|
Scrach
|
Dryness
|
Softness
|
Ovall
evalution
|
|
1 day
|
3.82
|
4.09
|
3.91
|
4.36
|
3.00
|
|
4
week
|
4.36
|
4.64
|
4.27
|
n.d
|
n.d
|
|
8
week
|
4.45
|
4.64
|
4.36
|
4.36
|
4.00
|
|
 |
|
|
